Research

Biophotonics

Head of Research: Daniel Côté

This sector is experiencing strong growth and has become one of the most rapidly developing axes at our research centre. The main activities underway target imaging, diagnostics, the development of analytical tools and therapeutics. Work in this sector is supported by various partnerships with hospital-based research centers, in particular the Quebec University Institute of Mental Health, the organization that collaborated with the COPL in obtaining a second Canada Excellence Research Chair, this one in neurophotonics. The Chairholder is Dr. Pierre Marquet who joined the COPL in 2015.

Theme 1 – Diagnostics
Keywords: Endoscopy. Imaging fiber probe. Multimodal microprobe. Fluorescence imaging. Raman Imaging. Coherent Raman Imaging. Coherent Raman spectroscopy. Biomarker tracking.

Researchers in this theme: Boudoux, Caroline ; Bérubé Lauzière, Yves ; Charette, Paul ; Côté, Daniel ; De Koninck, Yves ; Galstian, Tigran ; Leblond, Frédéric ; Messaddeq, Younès ; Meunier, Michel ; Piché, Michel ; Sheng, Yunlong ; Skorobogatiy, Maksim ; Vallée, Réal

Theme 2 – Therapeutics and surgery
Keywords: Surgery and Microsurgery. Optogenetics. Optical monitoring of neural activity. Longitudinal imaging. Stem cell migration. Parkinson’s disease,

Researchers in this theme: Boudoux, Caroline ; Boudreau, Denis ; Côté, Daniel ; De Koninck, Yves ; Leblond, Frédéric ; Messaddeq, Younès ; Meunier, Michel ; Sheng, Yunlong ; Vallée, Réal

Theme 3 – Analytical tools
Keywords: Molecular contrast. Spatial resolution. Cellular hyper-resolution. 3D imaging. Microscopy. Genetic material detection. Pathogen detection. Bacterial detection. Specific fluorescent optical probes. Cell capture. Optical tweezers. Micro-fluidic systems. In vivo structural and functional imaging. Neural and synaptic imaging. Holographic imaging.

Researchers in this theme: Allen, Claudine ; Boudreau, Denis ; Charette, Paul ; Côté, Daniel ; De Koninck, Yves ; Leblond, Frédéric ; Messaddeq, Younès ; Meunier, Michel ; Rainville, Simon ; Ritcey, Anna ; Vallée, Réal

 

 

Biophotonic probe
Several types of bacteria move around in their environment with the aid of long filaments called flagella. Bacterial flagella measure no more than 20 nm in diameter but can be observed with fluorescence microscopy. Here the genetic code of E.coli bacteria was modified to allow a fluorophore (Alexa Fluor 488) to be specifically attached to the filament's protein.
In vitro setup for in-depth study of the bacterial flagellum. Here a micropipette with an internal diameter of approx. 1 µm grasps an E.coli bacterium. Ultrafast laser pulses pierce the bacterium's membrane enabling access to the core of the cell as well as direct control of the flagellum's motor. The motor's rotation can be observed with high-speed fluorescence microscopy.
Centre d'optique, photonique et laser
2375 rue de la Terrasse, local 2104
Université Laval, Québec, Canada, G1V 0A6
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